RRML - Anti-tissue transglutaminase antibodies in patients with anti glutamate dehydrogenase positive type 1 diabetes mellitus

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Nr. 20(3)/2012

Anti-tissue transglutaminase antibodies in patients with anti glutamate dehydrogenase positive type 1 diabetes mellitus

Gabriela Gurau, Michaela Dobre, Aurel Nechita

Abstract:

The purpose of our study is to determine the prevalence of celiac disease related antibodies (anti-tissue transglutaminase, anti-tTG IgA) in patients with type 1 diabetes mellitus (T1DM) and to compare these results with the general population. We also evaluated the prevalence of anti-tTG IgA in the absence and presence of anti-glutamate dehydrogenase antibodies (anti-GAD) in diabetic subjects. The autoantibodies were evaluated with respect to the clinical status and diabetes control of the patients. The study included 111 children and young adults, 62 boys and 49 girls, with a mean age of 13.42 ± 6.00 years and a duration of diabetes which ranged from 0 to15 years, and 161 control subjects, age and sex matched. Patients who were positive were offered a gastroduodenoscopic examination. Anti-GAD autoantibodies were positive in 68.5% (76/111) patients with T1DM. In T1DM patients with anti-GAD positivity, we found a prevalence of positive anti-tTG IgA 3.94% (3/76) and on T1DM patients without anti-GAD, the anti-tTG IgA positivity was 2.85% (1/35) (nonsignificant differences). Anti-tTG IgA antibodies positivity was higher in patients with T1DM (4/111; 3.6%), compared to controls (1/161; 0.6%). Serological markers are useful in identifying celiac disease patients with T1DM. Celiac disease (CD) related antibodies weren’t more frequent in T1DM patients positive for anti-GAD and no age correlation was observed.

Keywords: celiac disease,diabetes mellitus,anti-tTGIgA,anti-GA

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Gurau G, Dobre M, Nechita A. Anti-tissue transglutaminase antibodies in patients with anti glutamate dehydrogenase positive type 1 diabetes mellitus. Rev Romana Med Lab. 2012;20(3):225-32