RRML - Lean body mass and leptin, but not fat mass are independent predictors of bone mass in postmenopausal women
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Dr. Adrian Man
   
 
Nr. 20(3)/2012
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Lean body mass and leptin, but not fat mass are independent predictors of bone mass in postmenopausal women

Corina Buţa, Carmen Vulpoi, Didona Ungureanu, Voichiţa Mogoş, Dumitru D. Brănișteanu


Abstract:

Body weight is positively correlated to bone mass. While gravity represents a stimulatory stress for bone turnover, endocrine function of adipocytes may also influence bone. We investigated the relative influence of weight, body composition and leptin upon lumbar bone mass in pre- and postmenopausal women. Materials and methods: This cross-sectional study included six groups varying from 8 to 15 pre- / postmenopausal volunteers with different weights (BMI < 25 kg/m2, overweight: BMI 25-30 kg/m2, and obese: BMI > 30 kg/m2). Lumbar bone mineral density (BMD) and body composition (BC) were evaluated by dual X ray absorptiometry (DXA), while serum leptin was evaluated by ELISA. Results: Lean and overweight postmenopausal women had lower lumbar BMD than premenopausal women (p < 0.05). Bone mass of obese postmenopausal women did not differ from that of premenopausal women. Body weight and compartments were positively correlated with bone mineral content. The best correlation was observed for lean mass (r2 = 0.47 for the whole group), which was an independent predictor of bone mass, irrespective of age (p < 0.05). Leptin was an independent predictor for bone mass only for postmenopausal women (p < 0.05). Conclusion: Increased body weight is associated with decreased bone loss after menopause. Lean mass predicts bone mass independently of body weight, irrespective of age. The beneficial role of fat mass and total body weight on bone mass through gravitational stress seems to be supplemented by possible direct effects of leptin on bone in postmenopausal women.

Keywords: bone,body composition,leptin,menopause,osteoporosis

 
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How to cite
Buţa C, Vulpoi C, Ungureanu D, Mogoş V, Brănișteanu DD. Lean body mass and leptin, but not fat mass are independent predictors of bone mass in postmenopausal women. Rev Romana Med Lab. 2012;20(3):215-23