RRML - Crevicular C-telopeptide and C-propeptide of type I collagen are markers of parodontal disease evolution in diabetic and non-diabetic patients
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Dr. Adrian Man

   
 
Nr. 20(2)/2012
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Crevicular C-telopeptide and C-propeptide of type I collagen are markers of parodontal disease evolution in diabetic and non-diabetic patients

Roxana I. Vasluianu, Didona Ungureanu, Daniela Jitaru, Andreea D. Ioanid, Norina C. Forna


Abstract:

The alveolar bone is the place where some permanent structural reshaping occurs through resorption and apposition processes induced by the modification of the forces direction on the level on odontal support, so that they withstand efficiently the mechanical stress. Collagen is the most abundant protein in the human body and at the same time, the most important one. The assessment of the C-telopeptide of type I collagen (CTx) and of the C-terminal propeptide of type I procollagen (PICP) was carried out on a lot of 174 patients, between 50-75 years old, out of which 130 were women and 44 men. The lot of patients was divided according to sex and pathology. The determination of the markers implied taking samples of crevicular fluid on the level of the gingival sulcus, with filter paper. The bone resorption rate was significantly modified (p<0.001) in the case of the patients with diabetes or osteoporosis compared to the witness lot whilst the evolution of the bone apposition was not significantly modified. From the results obtained in our study, we could draw the conclusion that the PICP marker of bone apposition was not correlated with the clinical pathology of the patients, unlike the CTx marker of bone resorption and atrophy of the alveolar bone that was significantly correlated from the statistical point of view with the clinical pathology of the investigated patients.

Keywords: C-telopeptide of the type I collagen - CTx,C-propeptide of the type I procollagen - PICP,crevicular fluid

 
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How to cite
Vasluianu RI, Ungureanu D, Jitaru D, Ioanid AD, Forna NC. Crevicular C-telopeptide and C-propeptide of type I collagen are markers of parodontal disease evolution in diabetic and non-diabetic patients. Rev Romana Med Lab. 2012;20(2):173-80