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Immune response in rats following administration of honey with sulfonamides residues Ionela D. Popa (Morariu), Elena C. Şchiriac, Didona Ungureanu, Rodica Cuciureanu
Abstract: Introduction. The aim of this paper was to study the immune response in rats after honey intake containing sulfonamides residues, by analysis and profiling of 12 cytokines, immunoglobulin E (IgE) and plasma eosinophils. Materials and methods. In order to evaluate the changes in serum values of the parameters involved in allergic-type hypersensitivity reactions, the variation of serum levels of cytokines: interleukin (IL)-2, IL-4, IL-6, IL-8, IL-10, vascular endothelial growth factor (VEGF), interferon gamma (IFNγ), tumor necrosis factor alpha (TNFα), IL-1α, IL-1β, monocyte chemoattractant protein-1 (MCP-1), epidermal growth factor (EGF), before and after sulfonamide containing honey administration in Wistar rats, was analyzed. The study was conducted on rats, which were divided into three groups: group 1 – control, group 2 – rats receiving honey containing sulfonamide residues for 5 days, and group 3 - rats receiving honey containing sulfonamide residues for 14 consecutive days, respectively. Serum cytokine levels were evaluated in two groups and compared with controls. Results and discussions. In both rats groups that had received honey with sulfonamides the levels of IL-4, IL-6, IL-8, IL-10, VEGF, IFNγ, TNFα, MCP-1, EGF, IgE and eosinophils were significantly increased compared with controls. Correlation between cytokine levels, IgE and eosinophils levels was also determined and found positive. Conclusions. The levels of the cytokines IL-4 and IL-10 along with IgE and eosinophils were increased 5–30 fold with a maximum response after 14 days’ exposure, the differences were statistically significant. Keywords: cytokines,eosinophils,sulfonamides,hypersensitivity |
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Popa (Morariu) ID, Şchiriac EC, Ungureanu D, Cuciureanu R. Immune response in rats following administration of honey with sulfonamides residues. Rev Romana Med Lab. 2012;20(1):63-72
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