RRML - Myeloid sarcoma presenting as a solitary skin nodule – case presentation

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Dr. Adrian Man

Nr. 20(1)/2012

Myeloid sarcoma presenting as a solitary skin nodule – case presentation

Mihai Turcu, Tibor Mezei, Emőke Horváth, Erzsébet Bendek Lázár


Myeloid sarcoma is a rare neoplasm, that according to the WHO classification represents a tumor mass consisting of myeloid blasts with or without maturation that occurs at an anatomical site other than the bone marrow. It typically occurs in the later decades of life. It can involve practically any site of the body, however there are some anatomical sites that are more frequently involved: skin, lymph nodes, gastrointestinal tract, soft tissue, bones and testis. We describe the case of a 78-year-old male patient with unremarkable past medical history that presented with multiple skin lesion consisting of reddish, slightly elevated nodules. After biopsy and histological examination, a diagnosis of non-Hodgkin B-cell lymphoma was ensued. Specific treatment was applied that caused the skin lesions to reside and disappear. After a brief period (4 months) a solitary skin nodule with central ulceration developed on the left anterior chest wall. The patient otherwise was asymptomatic without evidence of any hematological disorder or disease involving the skin. The histological and immunohistochemical findings revealed the diagnosis of myeloid sarcoma, with later evolution to acute myeloid leukaemia (AML).

Keywords: myeloid sarcoma,skin,acute myeloid leukemia

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How to cite
Turcu M, Mezei T, Horváth E, Bendek Lázár E. Myeloid sarcoma presenting as a solitary skin nodule – case presentation. Rev Romana Med Lab. 2012;20(1):33-8