RRML - The relationship between matrix GLA protein (MGP) and carotid stenosis

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Concept, Design & Programming
Dr. Adrian Man

Nr. 19(2)/2011

The relationship between matrix GLA protein (MGP) and carotid stenosis

Dana Pop, Adela Sitar-Taut, Elena Gligor, Gyorgy Bodizs, Mirela Cebanu, Smaranda Buduru, Dumitru Zdrenghea


Serum matrix GLA protein was correlated with vascular calcification and atherosclerosis risk factors, however the relationship with carotid stenosis was not studied insofar. Objectives: to study the relationship between matrix GLA protein and carotid stenosis and its degree. Methods: 60 patients were studied, 23 males and 37 females, aged 67.25 ± 9.42 years. Each patient was submitted to an Eco Doppler carotid examination, carotid stenosis being classified as insignificant <20%, moderate 20-50%, severe >50%. In each patient, matrix GLA protein was determined using ELISA method. Results: there were significant differences of matrix GLA protein serum level between subjects with (>20%) and without carotid stenosis (22.85 ± 2.92 nmol/L vs. 19.70 ± 3.06 nmol/L, p<0.0001). The values were also correlated with stenosis degree (<50% 21.48 ± 3.19 nmol/L vs. >50% 23.46 ± 3.83 nmol/L). It was possible to establish a cut-off value for severe stenosis (cut-off value 21.5 nmol/L, AUROC 0.637, sensibility 75%, specificity 55.8%). In turn, matrix GLA protein level concentration did not correlate with cardiovascular risk factors, no significant differences being registered in relationship with sex, hypertension (21.85 ± 3.45 nmol/L vs. 21.1 ± 2.36 nmol/L), diabetes mellitus (21.77 ± 3.49 vs. 21.74 ± 3.29 nmol/L), obesity (21.44 ± 3.82 vs. 21.87 ± 3.09 nmol/L) or smoking habit (20.91 ± 3.71 vs. 21.86 ± 3.29 nmol/L). Conclusion: serum matrix GLA protein level may be used as both arterial calcification and carotid atherosclerosis index.

Keywords: matrix GLA protein,carotid stenosis,cardiovascular risk factors

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How to cite
Pop D, Sitar-Taut A, Gligor E, Bodizs G, Cebanu M, Buduru S, et al. The relationship between matrix GLA protein (MGP) and carotid stenosis. Rev Romana Med Lab. 2011;19(2):169-75