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Dr. Adrian Man

   
 
Nr. 19(2)/2011
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The relationship between matrix GLA protein (MGP) and carotid stenosis

Dana Pop, Adela Sitar-Taut, Elena Gligor, Gyorgy Bodizs, Mirela Cebanu, Smaranda Buduru, Dumitru Zdrenghea


Abstract:

Serum matrix GLA protein was correlated with vascular calcification and atherosclerosis risk factors, however the relationship with carotid stenosis was not studied insofar. Objectives: to study the relationship between matrix GLA protein and carotid stenosis and its degree. Methods: 60 patients were studied, 23 males and 37 females, aged 67.25 ± 9.42 years. Each patient was submitted to an Eco Doppler carotid examination, carotid stenosis being classified as insignificant <20%, moderate 20-50%, severe >50%. In each patient, matrix GLA protein was determined using ELISA method. Results: there were significant differences of matrix GLA protein serum level between subjects with (>20%) and without carotid stenosis (22.85 ± 2.92 nmol/L vs. 19.70 ± 3.06 nmol/L, p<0.0001). The values were also correlated with stenosis degree (<50% 21.48 ± 3.19 nmol/L vs. >50% 23.46 ± 3.83 nmol/L). It was possible to establish a cut-off value for severe stenosis (cut-off value 21.5 nmol/L, AUROC 0.637, sensibility 75%, specificity 55.8%). In turn, matrix GLA protein level concentration did not correlate with cardiovascular risk factors, no significant differences being registered in relationship with sex, hypertension (21.85 ± 3.45 nmol/L vs. 21.1 ± 2.36 nmol/L), diabetes mellitus (21.77 ± 3.49 vs. 21.74 ± 3.29 nmol/L), obesity (21.44 ± 3.82 vs. 21.87 ± 3.09 nmol/L) or smoking habit (20.91 ± 3.71 vs. 21.86 ± 3.29 nmol/L). Conclusion: serum matrix GLA protein level may be used as both arterial calcification and carotid atherosclerosis index.

Keywords: matrix GLA protein,carotid stenosis,cardiovascular risk factors

 
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How to cite
Pop D, Sitar-Taut A, Gligor E, Bodizs G, Cebanu M, Buduru S, et al. The relationship between matrix GLA protein (MGP) and carotid stenosis. Rev Romana Med Lab. 2011;19(2):169-75