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Nr. 18(3)/2010
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Serum leptin levels in obese children and adolescents: relationship to age, gender, body mass index and lipid metabolism parameters

Oana Mărginean, Ana-Maria Pitea, Klara Brânzaniuc, Adina Huțanu, S. Voidăzan


Abstract:

The aim of the study was to analyze the relationship between leptin serum levels, body mass index and certain parameters of lipid and carbohydrate metabolism in children and adolescents with various degree of obesity. We assessed 86 children and adolescents (45 boys and 41 girls) between 6 and 18 years of age within the Ist Pediatric Clinic from Târgu Mureş; 68.60% of the children were overweight, 29.07% had class I obesity and 2.33% had class II obesity. Leptin serum levels were measured and compared with BMI, age and parameters of carbohydrate and lipid metabolism (blood glucose, cholesterol, triglycerides, HDL cholesterol, and LDL cholesterol). Leptin serum levels were increased in all overweight and obese adolescents: we found leptin serum levels of 45.69 ± 28.04 ng/mL in boys, and significantly higher values (72.96 ± 22.02 ng/mL) in girls. These values were positively correlated with BMI (r = 0,34 in boys and r = 0,44 in girls). A positive correlation was found between leptin, total cholesterol and LDL-cholesterol levels, in boys. No correlations were found between leptin and glycemia, triglycerides and HDL-cholesterol levels. Cholesterol, HDL- and LDL-cholesterol concentrations, as expected, were higher in mothers as compared to their children. The presence of high leptin concentrations in adolescents and children could indicate a predisposition to obesity in adult life.

Keywords: Obesity,children,leptin

 
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How to cite
Mărginean O, Pitea AM, Brânzaniuc K, Huțanu A, S. Serum leptin levels in obese children and adolescents: relationship to age, gender, body mass index and lipid metabolism parameters. Rev Romana Med Lab. 2010;18(3):71-8