RRML - A model for calculating measurement uncertainty in medical laboratories
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2020): 75%

Română English


Journal Metrics

Impact Factor 0.493
Five Year Impact Factor 0.531
SNIP 0.373
JCI 0.17


Advanced search


Top 10 downloaded articles
- December 2022 -
 
Downregulation of hsa-miR-4328... 5
Normality assessment, few para... 4
High DNAJA4 expression correla... 4
Setting up an own laboratory p... 4
New Para-Clinical Investigatio... 3
Genetic risk factors for throm... 3
miR-190, CDK1, MCM10 and NDC80... 3
The relationship between matri... 2
A model for calculating measur... 2
The Use of Infrared Spectrosco... 2

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Nr. 18(1)/2010
XML
TXT

A model for calculating measurement uncertainty in medical laboratories

Irina L. Dumitriu, Bogdan Gurzu, Simona M. Slǎtineanu, Liliana Foia, Traian Mutiu, Corina Şchiriac, Mioara Achirecesei, Maria Enea


Abstract:

Introduction: All medical laboratories that require recognition for competency assessment have to estimate the uncertainty of measurement of assay test results “where relevant and possible” (ISO 15189:2007 Medical laboratories - Particular requirements for quality and competence). The repeated quantitative examination of an analyte with the same method will offer more or less different results. This is happening because the outcome of an assay depends not only upon the analyte itself, but also upon few error factors that could yield doubts about the obtained result. The mathematical, quantitative expression of this doubt is known as uncertainty of measurement (UM). Methods: It is the responsibility of each medical laboratory to identify all error sources that can be quantified and converted in standard deviations that could be used to estimate the type A or B of uncertainty. In the case of Romanian medical laboratories, the European Accreditation (EA) accepted as reference documents for UM estimation the Guide to the Expression of Uncertainty in Measurement (GUM) and Romanian Standard SR ENV 13005. Discussion and conclusion: In this paper, authors present and discuss the modalities of UM estimation in two different situations: when the used reference materials (calibrators) are or are not traceable to certified reference materials (CRM). Complete and informative UM reporting can only lead to better decisions in healthcare.

Keywords: precision,accuracy,uncertainty of measurement,calibrator

 
  PDF Download full text PDF
(449 KB)
     
 
How to cite
Dumitriu IL, Gurzu B, Slǎtineanu SM, Foia L, Mutiu T, Şchiriac C, et al. A model for calculating measurement uncertainty in medical laboratories. Rev Romana Med Lab. 2010;18(1):65-77