RRML - Association of methionine synthase A2756G SNP, methionine synthase reductase A66G and male infertility
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2016): 55%

Română English


SCImago Journal & Country Rank


Advanced search


Top 10 downloaded articles
- June 2018 -
 
Innate Immune Mechanisms in My... 7
Eulogy for Professor Dr. Carme... 6
Effects of miR-99a on the migr... 6
Ischemic modified albumin incr... 4
Antiphosphatidylethanolamine A... 4
Could fibrinogen and hsCRP be ... 4
Phenotypic and molecular ident... 4
Influence of dietary supplemen... 3
The frequency of shiga-like to... 3
Diagnostic accuracy of red blo... 3

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Nr. 17(4)/2009
XML
TXT

Association of methionine synthase A2756G SNP, methionine synthase reductase A66G and male infertility

Marius F. Farcas, Adrian P. Trifa, Mariela Militaru, Flaviu A. Csernik, Tania O. Crisan, Radu A. Popp


Abstract:

The folate metabolic pathway consists of an important chain of reactions which lead to nucleic acid production and methylation of various substrates. Within this pathway MS, and MTRR, the enzyme which is responsible for the regeneration of MS, catalyzes the conversion of homocysteine to methionine. The MS A2756G and MTRR A66G variants are associated with reduced enzyme activity, increased homocysteine and reduced availability of SAM. We analyzed the distribution of these single nucleotide polymorphisms in the two genes in a case group of 65 infertile Romanian patients with idiopathic azoospermia or severe oligozoospermia and a control group of 67 Romanian men, to explore the possible association of the MS A2756G and MTRR A66G polymorphisms and male infertility. Using the polymerase chain reaction - restriction fragment length polymorphism technique (PCR-RFLP), the allele and genotype distribution of the two SNPs were investigated in both patients and controls. The frequencies of these polymorphisms in infertile patients were not significantly higher than those in controls. Our findings suggest that there is no significant association of SNP A2756G in the MS gene or SNP A66G in the MTRR gene with azoospermia or severe oligozoospermia, indicating that these polymorphisms would not be genetic risk factors for male infertility in our Romanian population group.

Keywords: infertility,homocysteine,folate,azoospermia,methylation

 
  PDF Download full text PDF
(124 KB)
     
 
How to cite
Farcas MF, Trifa AP, Militaru M, Csernik FA, Crisan TO, Popp RA. Association of methionine synthase A2756G SNP, methionine synthase reductase A66G and male infertility. Rev Romana Med Lab. 2009;17(4):17-24