RRML - Particularities of infective endocarditis. A retrospective study

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Dr. Adrian Man

Nr. 16(3)/2009

Particularities of infective endocarditis. A retrospective study

Ioan Ţilea, Brânduşa Ţilea, Horaţiu Suciu, Cristina Maria Tătar


Background: Despite of all progresses made in the management of infectious diseases and cardiovascular pathology, the incidence of infective endocarditis (IE) remains constant when comparing it to the pre-antibiotic era. The aim of the present study consists in evaluating the clinical, laboratory tests, etiological and therapeutic parameters in patients with IE. Methods: We conducted a retrospective study on 20 patients admitted in Third Medical Clinic – Dept. of Cardiology, First Infectious Diseases Clinic, Institute of Cardiovascular Disease and Transplantation of Targu Mures, Romania, over a period of 2 years, which were diagnosed with IE according to the Duke criteria. We studied socio-demographic parameters, co-morbidities, predisposing factors, the nature and the site of affected valves, clinical, bacteriological and therapeutic characteristics of the patients. Results: The patients’ age varied between 26 and 65 years; 12 (60%) of them were men and 8 (40%) women. 14 patients were diagnosed with IE and 6 with possible IE, localized on native valves – aortic valve (50%), mitral valve (40%), prosthetic valves (10%). The etiology was established in 14 patients and was confirmed by positive blood cultures as follows: coagulase-positive Staphylococcus aureus (8), Streptococcus pyogenes (1), Enterococcus spp. (1), coagulase-negative Staphylococcus (1), streptococi viridans (1), Gram negativ bacilli (1), fungi (1). Antibacterial therapy was applied according to the results of antibiotic susceptibility tests in 70% and empirically in 30% of the patients. Conclusion: In our study, Staphylococcus aureus held the first place in IE etiology on native and prosthetic valves. We have also noticed an increased incidence of community-associated methicillin-resistant Staphylococcus aureus (MRSA).

Keywords: infective endocarditis,etiological,clinical,therapeutic aspects

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How to cite
Ţilea I, Ţilea B, Suciu H, Tătar CM. Particularities of infective endocarditis. A retrospective study. Rev Romana Med Lab. 2009;16(3):41-7