RRML - Diagnostic, therapeutic and evolutive particularities of Lyme disease

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Dr. Adrian Man

Nr. 15(2)/2009

Diagnostic, therapeutic and evolutive particularities of Lyme disease

Brînduşa Ţilea, Carmen Chiriac, Ion Ţilea, Rodica Urcan, Graţiela Tripon, Mihai Gliga


Background: Among the emergent diseases which mankind is confronted with, nowadays we can mention Lyme borreliosis (LB), a zoonosis produced by bacteria from Borrelia type, transmitted by Ixodes ticks. Aim: to analyse incidence, clinical forms, diagnostic and post-therapeutic evolution of the patients with early LB. Material and methods: 260 patients, both gender, tick-bite, who we admitted in First Infectious Disease Clinic Targu Mures between May, 20 and September, 20, 2008, were retrospectively analysed. The diagnostic of LB was established using Centers for Disease Control and Prevention criteria: epidemiology, (history of tick bite), physical signs (skin, nervous and articular determinations) and for confirmation laboratory tests for determining antibodies anti Bb (IgM) from serum and cerebrospinal fluid (CSF), using enzyme-linked immunoassay (ELISA) technique, Virion/Serion kit. Results: Tick-bite was recognised by all 260 pts; there was a dominance of females (56.9%) against males (43.1%), with more patients from urban areas (57.7%) compared with rural areas (42.3%), 53.85% pts had skin manifestations, neurological signs were observed in 4.6% of the patients and articular involvement was encountered in 3.07% of all subjects. Serology was positive (IgM antibodies anti Bb) in 90 pts (34.6%). The therapy consisted of: Doxicyclin, Ceftriaxone, Amoxicilline+ Clavulanic acid, Azytromicyn. Conclusions: in our area, the incidence of Lyme borreliosis was higher in 2008 vs. 2007. Predominant clinical aspects were: cutaneous, and after them nervous and articular manifestations. Presence of IgM anti Bb antibodies confirmed the certain disease. Etiological therapy was efficient in all patients; no complications or sequele were noticed. Early etiologic therapy in Lyme borreliosis plays an important role in spirochetal eradication, in prevention of chronic infection.

Keywords: Lyme borreliosis,diagnosis,treatment

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How to cite
Ţilea B, Chiriac C, Ţilea I, Urcan R, Tripon G, Gliga M. Diagnostic, therapeutic and evolutive particularities of Lyme disease. Rev Romana Med Lab. 2009;15(2):55-60