RRML - Association between oxidized low-density lipoprotein cholesterol concentration and atherosclerosis
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Dr. Adrian Man

   
 
Nr. 15(2)/2009
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Association between oxidized low-density lipoprotein cholesterol concentration and atherosclerosis

Germaine Savoiu, Carmen Cristescu, Corina Serban, Cristina Dehelean, Simona Dragan, Oana Duicu, Lavinia Noveanu, Claudia Borza


Abstract:

Oxidized LDL (ox-LDL) is thought to play a key role in the inflammatory response in the arterial vessel wall. This study aimed to investigate the association between oxidized low density lipoprotein cholesterol and carotid intima-media thickness (IMT), a surrogate measure of atherosclerosis. Four groups of subjects were included in the study: a control group that included 12 normocholesterolemic healthy subjects (68% males, 32% females), 32 subjects with clinical signs of coronary artery disease (71% males, 29% females), 12 patients with arterial hypertension (60% males, 40% females), and 12 dyslipidemic patients (68% males, 32% females). Lipid profiles of the patients were measured by enzymatic methods. Ox-LDL was measured by a commercially available sandwich ELISA (Mercodia AB, Uppsala, Sweden) and carotid IMT by high-resolution B-mode ultrasound. Serum ox-LDL levels were higher in coronary artery disease patients (92.8 ± 8.12 U/L) and dyslipidemic patients (70 ± 16.24 U/L) compared with hypertensive (55.8 ± 10.84 U/L) and control subjects (53.7 ± 7.11 U/L). A positive, moderate correlation between ox-LDL and carotid IMT was found only in coronary artery disease group (R2 = 0.58, p<0.001). We did not found significant correlation between ox-LDL and carotid IMT hypertensive, dyslipidemic and control groups. These results indicate that ox-LDL can be considered a marker of carotid atherosclerosis, and suggest that measurement of ox-LDL-C gives useful information in the risk assessment for atherosclerotic disease.

Keywords: oxidized low-density lipoprotein,carotid intima-media thickness,atherosclerosis.

 
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How to cite
Savoiu G, Cristescu C, Serban C, Dehelean C, Dragan S, Duicu O, et al. Association between oxidized low-density lipoprotein cholesterol concentration and atherosclerosis. Rev Romana Med Lab. 2009;15(2):49-54