RRML - Multiparametric approach of prognostic factors in acute myeloid leukemia – a bicentric study
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2016): 55%

Română English


SCImago Journal & Country Rank


Advanced search


Top 10 downloaded articles
- July 2019 -
 
Simultaneous FLT3, NPM1 and DN... 11
Do we really need genetic test... 7
Genotype comparison of Candida... 7
Laboratory medicine in the era... 5
Antibiotic susceptibility and ... 4
Point-of-care testing in diabe... 4
Antibacterial activity of sele... 4
Multiplex ligation dependent p... 3
Expanding PVL positive MRSA He... 3
The utility of molecular genet... 3

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Nr. 14(1)/2009
XML
TXT

Multiparametric approach of prognostic factors in acute myeloid leukemia – a bicentric study

Anca Bacârea, Mariana Paţiu, Andrei Cucuianu, Delia Dima, Vladimir Bacârea, Bogdana Dorcioman, Minodora Dobreanu, Galafteon Oltean


Abstract:

Acute myeloid leukemias (AML) are a group of malignant hematologic disorders with varying clinical, morphologic, immunologic and molecular characteristics. Prognostic factors evaluation remains an important subject of study in order to improve the outcome of patients with AML, a disease with poor prognostic by itself. Establishing prognosis at the time of diagnosis is expected in order to stratify treatment. The aim of this study is to evaluate some prognostic factors in AML: age, leukocyte count, platelet count, FAB (French-American-British Cooperative Group) subtype, LDH serum level, immunophenotype at diagnosis. We included 59 patients with primary or secondary AML at the time of diagnostic, with complete investigation at the Hematology Department of Medical Clinic I in Tg-Mureş and at the Hematology Department of “Ion Chiricuţă” Cancer Institute Cluj-Napoca. Our results indicate that leukocyte count over 100000/µL, LDH serum activities over 1000 U/L and C34+CD56+ association are significant prognostic factors in AML at the time of diagnostic. FAB subtypes M0, M1, M4 significantly influenced complete remission. Due to the low number of cases prognostic evaluation of cytogenetics and molecular findings is not possible. These results represent an intermediary evaluation of patients, because the study is still underway.

Keywords: AML,prognostic,immunophenotyping

 
  PDF Download full text PDF
(99 KB)
     
 
How to cite
Bacârea A, Paţiu M, Cucuianu A, Dima D, Bacârea V, Dorcioman B, et al. Multiparametric approach of prognostic factors in acute myeloid leukemia – a bicentric study. Rev Romana Med Lab. 2009;14(1):41-8