RRML - Human papillomaviruses and cervical cancer

ISSN online: 2284-5623

ISSN-L: 1841-6624

Impact factor (2020): 1.027

Rejection rate (2020): 75%

Română English

Clarivate analytics (ISI) Impact factor

Advanced search

Top 10 downloaded articles
- May 2022 -
Approaching Risk Management in... 16
Screening of a novel BRCA2 mut... 14
Romanian Review of Laboratory ... 9
Matrix-assisted Laser Desorpti... 9
Proposal of a prediction model... 9
The evaluation of a diagnostic... 8
The evaluation of the preanaly... 7
Associations of serum expressi... 7
Downregulation of hsa-miR-4328... 7
Clinical significance of serum... 6

Log in

Concept, Design & Programming
Dr. Adrian Man

Nr. 8(3)/2007

Human papillomaviruses and cervical cancer

Liviu S. Enache, Elena L. Enache, Angela Borda, Minodora Dobreanu


The central causal role of the human papillomaviruses (HPV) in cervical cancer has been well established. The association is present in almost all cases of cervical cancer in the world. The ability of HPV oncogenes to interact with host cell cycle and growth regulators, as well as to elude the immune response and protect infected cells from apoptosis, can promote the persistence of the infection and the development of cervical carcinoma. However, only a small number of HPV infections progress to cancer, while the majority are eliminated by the host, suggesting that the presence of other cofactors is important in carcinogenesis. Several diagnostic tools for HPV infection have been developed, from basic cervical cytology screening to signal-amplified hybridization and the most recent real-time polymerase chain reaction techniques. HPV testing has been recently introduced in clinical practice and plays an increasing role in the management of women with abnormal cervical cytological findings. This article provides review of the recent literature on HPV infection epidemiology, pathogenesis and diagnosis.

Keywords: Human papillomavirus,cervical cancer,pathogenesis,diagnosis.

  PDF Download full text PDF
(243 KB)
How to cite
Enache LS, Enache EL, Borda A, Dobreanu M. Human papillomaviruses and cervical cancer. Rev Romana Med Lab. 2007;8(3):26-44