RRML - Bone status and aortic calcifications in chondrocalcinosis patients
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2016): 55%

Română English


SCImago Journal & Country Rank


Advanced search


Top 10 downloaded articles
- April 2020 -
 
Variability of ex-vivo stimula... 5
The direct deleterious effect ... 5
A chronic hepatitis B patient ... 4
Relationships between serum pr... 4
Validation of GOD / PAP method... 3
Romanian Review of Laboratory ... 3
Undetectable hemoglobin in a p... 3
The role of neutrophil to lymp... 3
An experimental in-vitro study... 2
Systemic interleukins levels i... 2

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Ahead of print DOI:10.2478/rrlm-2020-0019
XML
TXT

Research article

Bone status and aortic calcifications in chondrocalcinosis patients

Paulina Vele, Ciprian Nicolae Silaghi, Laura Otilia Damian, Siao-Pin Simon, Alexandra Craciun, Simona Rednic

Correspondence should be addressed to: Paulina Vele

Abstract:

Aim: We aimed to examine the association between several circulating bone turnover markers [ osteocalcin (OC), osteoprotegerin (OPG), beta-CrossLaps (β-CTx)], hip and spine bone mineral density (BMD) and abdominal aortic calcification (AAC) in patients with chondrocalcinosis (CC). Methods: Thirty-six patients with CC and thirty-seven controls were consecutively enrolled in this pilot case-control, cross-sectional study. The following parameters were assessed: serum levels of OC, OPG and β-CTx by enzyme-linked immunosorbent assay (ELISA); hip and spine BMD by dual-energy X-ray absorptiometry and AAC score by lateral radiography. Results: Patients with CC had higher levels of serum bone turnover markers and AAC score than the control group: OC [6.5 (3.5-9.9) vs 4.5 (2.6-7.2) ng/ml; p=0.05], OPG [(7.7 (6.2-9.4) vs 6.5 (5.5-8.12) pmol/ml; p=0.02], β-CTx [6078 (5870-6171) vs 5851 (5465-6109) pg/ml; p=0.02] and AAC score (3.6±6.2 vs 0.5±2; p=0.006). Conversely, even if statistical significance was not reached, hip and spine BMD was lower in patients with CC. Additionally, we found a positive correlation between OPG and AAC, but also between OPG and osteoporosis in patients with CC. Conclusion: Patients with CC are characterized by higher circulating OC, OPG and β-CTx. The presence of AAC was more common in patients with CC, being only associated with serum OPG.

Keywords: chondrocalcinosis, osteocalcin, osteoprotegerin, beta cross laps, abdominal aortic calcifications

Received: 25.11.2019
Accepted: 19.2.2020
Published: 5.3.2020

 
  PDF Download full text PDF
(422 KB)