RRML - Antiphosphatidylethanolamine Antibodies and Deep Vein Thrombosis in Lupus Patients with Antiphospholipid Syndrome
AMLR

ISSN online: 2284-5623

ISSN-L: 1841-6624

Rejection rate (2016): 55%

Română English


SCImago Journal & Country Rank


Advanced search


Top 10 downloaded articles
- September 2018 -
 
Rationale and Design of a Pros... 12
Biomarkers in heart failure: f... 11
Romanian Review of Laboratory ... 9
Postoperative interleukin-8 le... 8
Serum hs-CRP, YKL-40 and brain... 6
Biomarkers in Obesity... 6
Phenotypic and molecular ident... 5
Plasma phosphorylated neurofil... 4
Antibiotic susceptibility and ... 4
Candida albicans isolates from... 4

Log in

Concept, Design & Programming
Dr. Adrian Man

   
 
Nr. 26(2)/2018 DOI:10.2478/rrlm-2018-0009
XML
TXT

Short communication

Antiphosphatidylethanolamine Antibodies and Deep Vein Thrombosis in Lupus Patients with Antiphospholipid Syndrome

Simona Caraiola, Ciprian Jurcuț, Alina Dima, Cristian Băicuș, Anda Băicuș

Correspondence should be addressed to: Alina Dima

Abstract:

Backgroud. Which factors determine venous thrombotic events in some antiphospholipid syndrome (APS) patients and arterial thrombosis or conditions related to pregnancy in others has not been established yet. Purpose. The aim of this study was to search the antiphospholipid antibodies (APLAs) correlates in regard to deep vein thrombosis (DVT) in patients with systemic lupus erythematosus (SLE) and APS. Methods. Twenty-nine patients fulfilling the criteria of both SLE and APS were included. Complete anamnesis and clinical examination was performed on inclusion. Also, for all patients, disease activity was assessed by the SLEDAI score. An extended APLAs profile, ten Abs, was searched. Results. The titers of IgG anticardiolipin (aCL), IgG anti-β2 glycoprotein I (aβ2GPI), IgG antiphosphatidylethanolamine (aPE), and also of IgG antiprothrombin (aPT) were significant higher in patients with DVT history. After analysis by ROC curve and univariate logistic regression, the strongest association was found for IgG aPE. Also, in multivariate analysis, SLEDAI score correlated with the DVT antecedents. Conclusions. IgG aPE might be involved in DVT pathogenic pathways in patients with SLE and APS as their titers remain significantly higher in patients with previous DVT. Lupus patients with DVT events represent a subgroup of patients with more severe underlying pathology.

Keywords: antiphosphatidylethanolamine antibodies, antiphospholipid syndrome, deep vein thrombosis, systemic lupus erythematosus

Received: 16.11.2017
Accepted: 14.2.2018
Published: 7.3.2018

 
  PDF Download full text PDF
(476 KB)
     
 
How to cite
Caraiola S, Jurcuț C, Dima A, Băicuș C, Băicuș A. Antiphosphatidylethanolamine Antibodies and Deep Vein Thrombosis in Lupus Patients with Antiphospholipid Syndrome. Rev Romana Med Lab. 2018;26(2):243-50. DOI:10.2478/rrlm-2018-0009